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Informatics and standards for nanomedicine technology.

TitleInformatics and standards for nanomedicine technology.
Publication TypeJournal Article
Year of Publication2011
AuthorsThomas DG, Klaessig F, Harper S, Fritts M, Hoover MD, Gaheen S, Stokes TH, Reznik-Zellen R, Freund ET, Klemm JD, Paik DS, Baker N
JournalWiley Interdiscip Rev Nanomed Nanobiotechnol
Date Published2011 Jun 30

There are several issues to be addressed concerning the management and effective use of information (or data), generated from nanotechnology studies in biomedical research and medicine. These data are large in volume, diverse in content, and are beset with gaps and ambiguities in the description and characterization of nanomaterials. In this work, we have reviewed three areas of nanomedicine informatics: information resources; taxonomies, controlled vocabularies, and ontologies; and information standards. Informatics methods and standards in each of these areas are critical for enabling collaboration; data sharing; unambiguous representation and interpretation of data; semantic (meaningful) search and integration of data; and for ensuring data quality, reliability, and reproducibility. In particular, we have considered four types of information standards in this article, which are standard characterization protocols, common terminology standards, minimum information standards, and standard data communication (exchange) formats. Currently, because of gaps and ambiguities in the data, it is also difficult to apply computational methods and machine learning techniques to analyze, interpret, and recognize patterns in data that are high dimensional in nature, and also to relate variations in nanomaterial properties to variations in their chemical composition, synthesis, characterization protocols, and so on. Progress toward resolving the issues of information management in nanomedicine using informatics methods and standards discussed in this article will be essential to the rapidly growing field of nanomedicine informatics. WIREs Nanomed Nanobiotechnol 2011 DOI: 10.1002/wnan.152 This article is a U.S. Government work, and as such, is in the public domain in the United States of America. For further resources related to this article, please visit the WIREs website.

Alternate JournalWiley Interdiscip Rev Nanomed Nanobiotechnol
PubMed ID21721140
PubMed Central IDPMC3189420
Grant ListU01 NS073457-01 / NS / NINDS NIH HHS / United States
U54 CA119342-05 / CA / NCI NIH HHS / United States
U54 HG004028-07 / HG / NHGRI NIH HHS / United States

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